Detalhe da pesquisa
1.
Novel non-HAP class A HBV capsid assembly modulators have distinct in vitro and in vivo profiles.
J Virol
; 97(10): e0072223, 2023 10 31.
Artigo
em Inglês
| MEDLINE | ID: mdl-37754761
2.
Class A capsid assembly modulator RG7907 clears HBV-infected hepatocytes through core-dependent hepatocyte death and proliferation.
Hepatology
; 78(4): 1252-1265, 2023 10 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-37102495
3.
Tumor Regression upon Intratumoral and Subcutaneous Dosing of the STING Agonist ALG-031048 in Mouse Efficacy Models.
Int J Mol Sci
; 24(22)2023 Nov 13.
Artigo
em Inglês
| MEDLINE | ID: mdl-38003463
4.
ALG-097111, a potent and selective SARS-CoV-2 3-chymotrypsin-like cysteine protease inhibitor exhibits in vivo efficacy in a Syrian Hamster model.
Biochem Biophys Res Commun
; 555: 134-139, 2021 05 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-33813272
5.
An in vivo duck hepatitis B virus model recapitulates key aspects of nucleic acid polymer treatment outcomes in chronic hepatitis B patients.
Antiviral Res
; 224: 105835, 2024 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-38401714
6.
NVC-422 inactivates Staphylococcus aureus toxins.
Antimicrob Agents Chemother
; 57(2): 924-9, 2013 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-23208720
7.
Sulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity.
Bioorg Med Chem Lett
; 23(20): 5650-3, 2013 Oct 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-23999044
8.
The Substitutions L50F, E166A, and L167F in SARS-CoV-2 3CLpro Are Selected by a Protease Inhibitor In Vitro and Confer Resistance To Nirmatrelvir.
mBio
; 14(1): e0281522, 2023 02 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-36625640
9.
Development of tetravalent, bispecific CCR5 antibodies with antiviral activity against CCR5 monoclonal antibody-resistant HIV-1 strains.
Antimicrob Agents Chemother
; 55(5): 2369-78, 2011 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-21300827
10.
Epitope switching as a novel escape mechanism of HIV to CCR5 monoclonal antibodies.
Antimicrob Agents Chemother
; 54(2): 734-41, 2010 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-19995923
11.
Exploration of a new series of CCR5 antagonists: multi-dimensional optimization of a sub-series containing N-substituted pyrazoles.
Bioorg Med Chem Lett
; 20(16): 4753-6, 2010 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20643548
12.
Synthesis, SAR and evaluation of [1,4']-bipiperidinyl-4-yl-imidazolidin-2-one derivatives as novel CCR5 antagonists.
Bioorg Med Chem Lett
; 20(11): 3219-22, 2010 Jun 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20457517
13.
Evaluation of a 3-amino-8-azabicyclo[3.2.1]octane replacement in the CCR5 antagonist maraviroc.
Bioorg Med Chem Lett
; 20(5): 1674-6, 2010 Mar 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-20137937
14.
Evaluation of secondary amide replacements in a series of CCR5 antagonists as a means to increase intrinsic membrane permeability. Part 1: Optimization of gem-disubstituted azacycles.
Bioorg Med Chem Lett
; 20(2): 704-8, 2010 Jan 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20004099
15.
Evaluation of amide replacements in CCR5 antagonists as a means to increase intrinsic permeability. Part 2: SAR optimization and pharmacokinetic profile of a homologous azacyle series.
Bioorg Med Chem Lett
; 20(22): 6802-7, 2010 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20855212
16.
Evaluation of a 4-aminopiperidine replacement in several series of CCR5 antagonists.
Bioorg Med Chem Lett
; 20(6): 1830-3, 2010 Mar 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20176481
17.
Novel hexahydropyrrolo[3,4-c]pyrrole CCR5 antagonists.
Bioorg Med Chem Lett
; 20(10): 3116-9, 2010 May 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-20417098
18.
Regulation of gene transcription by thyroid hormone receptor ß agonists in clinical development for the treatment of non-alcoholic steatohepatitis (NASH).
PLoS One
; 15(12): e0240338, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-33306682
19.
Evaluation of SARS-CoV-2 3C-like protease inhibitors using self-assembled monolayer desorption ionization mass spectrometry.
Antiviral Res
; 182: 104924, 2020 10.
Artigo
em Inglês
| MEDLINE | ID: mdl-32896566
20.
Synthesis and Anti-HCV Activity of Sugar-Modified Guanosine Analogues: Discovery of AL-611 as an HCV NS5B Polymerase Inhibitor for the Treatment of Chronic Hepatitis C.
J Med Chem
; 63(18): 10380-10395, 2020 09 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-32816483